Pericardium morphogenesis

Across TCGA patient cohorts, RNA activity of the Pericardium morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GOLGB1, ADGRF5, and ROBO4_S823, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pericardium morphogenesis activity versus GOLGB1 in BRCA (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GOLGB1 →	-0.201	-0.043	.004	.002	3	5
LSCC	ADGRF5 →	+0.208	+0.048	.009	.006	2	6
UCEC	ROBO4_S823 →	+0.478	+0.079	.005	<.001	3	4
OV	SERPINA10 →	+0.619	+0.074	<.001	.009	3	4
UCEC	SLC9A3R1 →	-0.593	-0.062	<.001	.006	3	4
OV	CENPV →	+0.484	+0.068	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003344 vs GOLGB1 — BRCA

Explore this scatter interactively →