Pericardium morphogenesis

Across TCGA patient cohorts, RNA activity of the Pericardium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXNP6, ANKRD49P1, and ZNF17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pericardium morphogenesis activity versus TXNP6 in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TXNP6 →	+0.349	+0.642	.002	.003	3	4
LUAD	ANKRD49P1 →	+0.368	+0.978	.001	<.001	3	4
PDAC	ZNF17 →	+0.230	+0.524	<.001	.004	3	4
LUAD	HSPA8P19 →	+0.190	+0.546	.001	.006	3	4
PDAC	VIM →	+0.549	+0.682	<.001	<.001	3	4
GBM	MAPK14 →	+0.158	+0.739	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003344 vs TXNP6 — GBM

Explore this scatter interactively →