Pericardium morphogenesis

Across TCGA cell cohorts, RNA activity of the Pericardium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAG4, RRH, and ENTPD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BAG4 grouped by Pericardium morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	BAG4 →	+0.526	+1.155	.001	<.001	3	4
KIDNEY	RRH →	-0.115	-1.454	<.001	<.001	3	4
KIDNEY	ENTPD4 →	+0.909	+1.466	.006	<.001	3	4
SOFT_TISSUE	DNAJC6 →	-1.281	-1.250	.009	.003	3	4
LUNG_NSCLC_LUSC	ETNK2 →	+1.760	+1.527	.004	.002	2	5
BREAST	SEC61B →	+0.406	+0.850	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAG4 by Pericardium morphogenesis activity — STOMACH

Explore this box plot interactively →