Cilium movement

Across TCGA cell cohorts, RNA activity of the Cilium movement pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRGN, CHN2, and GCG, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRGN grouped by Cilium movement-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SRGN →	+2.132	+0.138	.001	.002	2	7
LIVER	CHN2 →	-2.624	-0.172	<.001	.006	3	5
BLOOD_Leukemia	GCG →	+0.112	+0.308	.001	<.001	2	6
BREAST	FLAD1 →	-0.767	-0.142	.001	<.001	3	5
BONE	NBPF12 →	-1.014	-0.388	.003	.001	3	5
BONE	CHTOP →	-0.572	-0.365	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRGN by Cilium movement activity — BREAST

Explore this box plot interactively →