Cilium movement

Across TCGA cell cohorts, RNA activity of the Cilium movement pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHMP7, HSPD1, and GYG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cilium movement activity versus CHMP7 in STOMACH (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CHMP7 →	+0.961	+0.424	.001	<.001	3	5
OVARY	HSPD1 →	+0.583	+0.379	.003	<.001	3	4
LIVER	GYG1 →	+0.902	+0.422	<.001	<.001	3	4
LUNG_SCLC	AP4S1 →	+0.936	+0.286	.005	.002	3	4
URINARY_TRACT	E2F1 →	+1.022	+0.503	<.001	.005	3	4
LUNG_SCLC	ASTE1 →	+0.469	+0.241	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003341 vs CHMP7 — STOMACH

Explore this scatter interactively →