Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP1, SIGLEC10, and TRIM14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis activity versus GBP1 in LUAD (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GBP1 →	+0.802	+0.113	.001	<.001	3	4
LUAD	SIGLEC10 →	+0.602	+0.096	<.001	.009	3	4
COAD	TRIM14 →	+0.534	+0.086	.001	<.001	3	3
COAD	BRCA1 →	+0.510	+0.082	.007	.006	3	3
UCEC	RMI2 →	+0.734	+0.175	<.001	<.001	3	3
COAD	FAM83H →	+0.666	+0.079	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003339 vs GBP1 — LUAD

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