Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JOSD1, ANXA3, and LMLN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JOSD1 grouped by Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	JOSD1 →	-0.560	-1.885	.001	.001	3	4
STOMACH	ANXA3 →	-3.471	-1.384	.002	.001	3	4
SKIN	LMLN →	+0.586	+0.973	<.001	<.001	3	4
LUNG_SCLC	GNG11 →	+2.141	+1.226	.004	<.001	3	4
LARGE_INTESTINE	TM2D1 →	-0.438	-0.837	.004	.003	3	4
LARGE_INTESTINE	STARD4 →	-0.894	-1.274	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JOSD1 by Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis activity — BONE

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