Metanephros morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephros morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNPY4, LOXL2, and COL1A2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephros morphogenesis activity versus CNPY4 in LSCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CNPY4 →	+0.410	+0.044	<.001	.006	3	6
LSCC	LOXL2 →	+0.923	+0.055	<.001	.003	3	5
OV	COL1A2 →	+0.557	+0.047	.007	.005	3	5
LSCC	COL3A1 →	+0.675	+0.054	<.001	.001	3	5
HNSC	SH3BP4_S246 →	+0.363	+0.046	.004	.002	3	5
LSCC	SFT2D2 →	-0.361	-0.057	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003338 vs CNPY4 — LSCC

Explore this scatter interactively →