Metanephros morphogenesis

Across TCGA cell cohorts, RNA activity of the Metanephros morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS13B, PPP1R3E, and PCID2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS13B grouped by Metanephros morphogenesis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	VPS13B →	-1.137	-1.238	.008	.009	3	4
URINARY_TRACT	PPP1R3E →	-1.490	-1.535	.002	<.001	3	3
PANCREAS	PCID2 →	-1.117	-0.793	<.001	.002	3	3
PANCREAS	FARP1 →	-1.228	-0.531	.002	.004	3	3
PANCREAS	ING1 →	-0.815	-0.738	<.001	.006	3	3
PANCREAS	CD7 →	+0.498	+0.570	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS13B by Metanephros morphogenesis activity — BLOOD_Lymphoma

Explore this box plot interactively →