Metanephros morphogenesis

Across TCGA cell cohorts, RNA activity of the Metanephros morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCYT1B, HMOX2, and LSR, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephros morphogenesis activity versus PCYT1B in OVARY (Pearson r = -0.99).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PCYT1B →	-1.244	-1.726	.003	<.001	1	1
OVARY	HMOX2 →	+1.535	+1.726	.008	<.001	1	1
OVARY	LSR →	+1.564	+1.726	.003	<.001	1	1
OVARY	RFC5 →	-0.970	-1.726	.004	<.001	1	1
OVARY	QKI →	-1.295	-1.726	.009	<.001	1	1
OVARY	BTN2A1 →	-0.725	-1.726	.001	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003338 vs PCYT1B — OVARY

Explore this scatter interactively →