Metanephros morphogenesis

Across TCGA cell cohorts, RNA activity of the Metanephros morphogenesis pathway is significantly associated with the drug response of multiple features, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Methotrexate, CRT0105950, and rTRAIL, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Methotrexate grouped by Metanephros morphogenesis-low versus -high activity in OVARY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Methotrexate →	+1.789	+1.726	.011	<.001	1	1
OVARY	CRT0105950 →	-0.559	-1.726	.041	<.001	1	1
OVARY	rTRAIL →	-0.469	-1.726	.016	<.001	1	1
OVARY	Doxorubicin →	+0.665	+1.726	.049	<.001	1	1
OVARY	BPTES →	-0.740	-1.726	.046	<.001	1	1
OVARY	Taselisib →	+1.110	+1.726	.044	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Methotrexate by Metanephros morphogenesis activity — OVARY

Explore this box plot interactively →