Mesenchymal to epithelial transition involved in metanephros morphogenesis

Across TCGA patient cohorts, RNA activity of the Mesenchymal to epithelial transition involved in metanephros morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMO, RNF215, and LIF, each associated with the pathway in up to 22 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal to epithelial transition involved in metanephros morphogenesis activity versus SMO in ESCA (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	SMO →	+1.244	+0.046	<.001	<.001	3	22
KICH	RNF215 →	+0.746	+0.095	<.001	<.001	2	18
UCS	LIF →	+1.434	+0.089	.005	.004	1	18
KIRP	MAP3K12 →	+0.635	+0.075	<.001	<.001	3	16
KIRP	WDR19 →	+0.733	+0.079	<.001	<.001	3	16
KIRP	RHOQ-AS1 →	+0.353	+0.084	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003337 vs SMO — ESCA

Explore this scatter interactively →