Mesenchymal to epithelial transition involved in metanephros morphogenesis

Across TCGA patient cohorts, RNA activity of the Mesenchymal to epithelial transition involved in metanephros morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FLNA_S968, PLOD1, and RPS6KA5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal to epithelial transition involved in metanephros morphogenesis activity versus FLNA_S968 in LUAD (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FLNA_S968 →	+1.004	+0.088	<.001	<.001	3	7
COAD	PLOD1 →	+0.479	+0.088	<.001	<.001	3	7
BRCA	RPS6KA5 →	-0.526	-0.070	<.001	<.001	3	6
COAD	CCN1 →	+0.695	+0.080	<.001	<.001	3	6
COAD	IKBIP →	+0.439	+0.082	<.001	<.001	3	6
CCRCC	NNMT →	+0.592	+0.064	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003337 vs FLNA_S968 — LUAD

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