Mesenchymal to epithelial transition involved in metanephros morphogenesis

Across TCGA patient cohorts, RNA activity of the Mesenchymal to epithelial transition involved in metanephros morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLN, MAMDC2, and ADAMTS9-AS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal to epithelial transition involved in metanephros morphogenesis activity versus PLN in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLN →	+0.894	+0.362	<.001	<.001	3	4
COAD	MAMDC2 →	+0.739	+0.215	.004	<.001	3	4
GBM	ADAMTS9-AS2 →	+0.731	+0.623	<.001	<.001	3	4
GBM	CCDC80 →	+0.808	+0.820	.004	<.001	3	4
LSCC	FMOD →	+0.730	+0.292	<.001	.004	3	4
LSCC	ENTPD1 →	+0.302	+0.174	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003337 vs PLN — LSCC

Explore this scatter interactively →