Mesenchymal to epithelial transition involved in metanephros morphogenesis

Across TCGA cell cohorts, RNA activity of the Mesenchymal to epithelial transition involved in metanephros morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA2013, UBXN2B, and AVPR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIAA2013 grouped by Mesenchymal to epithelial transition involved in metanephros morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KIAA2013 →	+0.498	+1.464	.004	.005	3	3
LIVER	UBXN2B →	-0.821	-1.944	.004	<.001	3	3
URINARY_TRACT	AVPR2 →	-0.150	-1.143	<.001	.007	2	4
OVARY	ID1 →	+1.455	+0.632	.002	.005	3	3
PANCREAS	CLN5 →	-0.925	-1.186	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	PARVA →	-0.643	-0.276	.004	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIAA2013 by Mesenchymal to epithelial transition involved in metanephros morphogenesis activity — LIVER

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