Keratinocyte development

Across TCGA patient cohorts, RNA activity of the Keratinocyte development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARMIL2_S1381, GNG2, and RCSD1_S216, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinocyte development activity versus CARMIL2_S1381 in HNSC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CARMIL2_S1381 →	-0.862	-0.052	<.001	.009	3	6
LSCC	GNG2 →	-0.281	-0.056	<.001	.001	3	6
LUAD	RCSD1_S216 →	-0.675	-0.041	.003	.003	3	5
LUAD	IKZF3 →	-0.208	-0.030	.004	.009	3	5
OV	SFN →	+1.049	+0.095	.003	<.001	3	5
LSCC	SDC1 →	+0.529	+0.070	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003334 vs CARMIL2_S1381 — HNSC

Explore this scatter interactively →