Keratinocyte development

Across TCGA patient cohorts, RNA activity of the Keratinocyte development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA3, MEIS3, and TTF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinocyte development activity versus ITGA3 in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ITGA3 →	+1.127	+0.749	<.001	.001	3	6
UCEC	MEIS3 →	+1.013	+0.292	<.001	<.001	3	5
UCEC	TTF2 →	-0.629	-0.299	<.001	.005	3	5
UCEC	TSHZ3 →	+1.140	+0.487	<.001	<.001	3	5
UCEC	COL6A2 →	+0.850	+0.214	<.001	.006	3	5
PDAC	EDNRA →	+1.168	+0.427	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003334 vs ITGA3 — LSCC

Explore this scatter interactively →