Keratinocyte development

Across TCGA cell cohorts, RNA activity of the Keratinocyte development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUB, F8A1, and NFKBIA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUB grouped by Keratinocyte development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TUB →	-2.023	-2.143	.001	<.001	3	4
BONE	F8A1 →	-1.637	-2.033	.009	<.001	3	4
SKIN	NFKBIA →	-0.987	-0.692	<.001	.005	3	3
BREAST	KANSL1 →	-0.859	-0.929	.001	.003	3	3
BREAST	OBSCN →	-1.633	-1.110	<.001	<.001	3	3
LIVER	ZNF776 →	+0.895	+2.220	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUB by Keratinocyte development activity — SOFT_TISSUE

Explore this box plot interactively →