Keratinocyte development

Across TCGA cell cohorts, RNA activity of the Keratinocyte development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFPI, ITGAV, and WDR89, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TFPI grouped by Keratinocyte development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TFPI →	-0.235	-0.416	.007	.003	3	6
LUNG_NSCLC_LUSC	ITGAV →	+0.714	+0.467	<.001	<.001	3	5
URINARY_TRACT	WDR89 →	+0.277	+0.611	<.001	<.001	3	5
CNS	PLRG1 →	-0.338	-0.674	.001	.007	3	5
BREAST	KCNB1 →	-0.129	-0.256	.009	.003	3	5
LUNG_NSCLC_LUSC	HM13 →	-0.291	-0.418	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TFPI by Keratinocyte development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →