Amino acid transmembrane transport

Across TCGA patient cohorts, RNA activity of the Amino acid transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AMPD3, FGR, and HCK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid transmembrane transport activity versus AMPD3 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AMPD3 →	+0.703	+0.071	<.001	<.001	3	8
COAD	FGR →	+0.602	+0.016	.001	.008	3	7
GBM	HCK →	+0.628	+0.048	<.001	<.001	3	7
COAD	MNDA →	+1.121	+0.030	<.001	<.001	3	7
COAD	RAB31 →	+0.379	+0.018	<.001	<.001	3	7
GBM	APOBR →	+0.472	+0.051	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003333 vs AMPD3 — GBM

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