Amino acid transmembrane transport

Across TCGA patient cohorts, RNA activity of the Amino acid transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL14A1, ITM2A, and CHRDL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid transmembrane transport activity versus COL14A1 in PDAC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	COL14A1 →	-0.741	-0.626	.003	.004	3	6
LUAD	ITM2A →	-0.714	-0.567	.001	.002	3	5
BRCA	CHRDL1 →	-1.613	-0.704	<.001	<.001	3	5
HNSC	PTGIS →	-1.271	-0.285	.002	.004	3	5
HNSC	CYP1B1 →	-1.306	-0.272	<.001	.005	3	5
BRCA	FDCSP →	-2.890	-0.777	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003333 vs COL14A1 — PDAC

Explore this scatter interactively →