Amino acid transmembrane transport

Across TCGA cell cohorts, RNA activity of the Amino acid transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMP2, CGB8, and CENPV, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid transmembrane transport activity versus LAMP2 in LARGE_INTESTINE (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LAMP2 →	+0.798	+0.161	<.001	.006	3	8
UPPER_AERODIGESTIVE_TRACT	CGB8 →	+2.434	+0.189	<.001	.002	3	6
BONE	CENPV →	-2.711	-0.590	<.001	<.001	3	6
OESOPHAGUS	IFNE →	+1.190	+0.216	.003	<.001	3	5
BREAST	ZBTB24 →	-0.608	-0.222	.002	.005	3	5
STOMACH	ARRB2 →	-1.312	-0.315	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003333 vs LAMP2 — LARGE_INTESTINE

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