Regulation of extracellular matrix constituent secretion

Across TCGA patient cohorts, RNA activity of the Regulation of extracellular matrix constituent secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCF4, SMARCA4, and STON1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extracellular matrix constituent secretion activity versus NCF4 in GBM (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCF4 →	+0.478	+0.084	<.001	<.001	3	5
GBM	SMARCA4 →	-0.306	-0.073	<.001	<.001	3	4
CCRCC	STON1 →	+0.701	+0.081	.002	.001	3	4
OV	TINAGL1 →	+0.487	+0.057	.004	.003	3	4
GBM	TLN1 →	+0.249	+0.066	<.001	<.001	3	4
CCRCC	TMEM134_S93 →	-0.733	-0.107	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003330 vs NCF4 — GBM

Explore this scatter interactively →