Regulation of extracellular matrix constituent secretion

Across TCGA patient cohorts, RNA activity of the Regulation of extracellular matrix constituent secretion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEDAG, COMP, and AXL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extracellular matrix constituent secretion activity versus MEDAG in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MEDAG →	+0.997	+0.459	<.001	<.001	3	5
PDAC	COMP →	+1.180	+0.828	.005	<.001	3	5
UCEC	AXL →	+0.568	+0.718	.008	.008	3	5
BRCA	ADRA2A →	+0.761	+0.296	.003	.002	3	5
BRCA	RGCC →	+0.831	+0.582	<.001	<.001	3	5
PDAC	GAS1 →	+0.792	+0.565	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003330 vs MEDAG — BRCA

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