Type B pancreatic cell development

Across TCGA patient cohorts, RNA activity of the Type B pancreatic cell development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLIT3, PEAK1, and TXNDC5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type B pancreatic cell development activity versus SLIT3 in PDAC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLIT3 →	+0.343	+0.040	<.001	<.001	3	6
PDAC	PEAK1 →	+0.204	+0.053	<.001	<.001	3	6
LSCC	TXNDC5 →	+0.418	+0.043	.002	.001	3	6
GBM	RBM47 →	-0.483	-0.061	.003	<.001	3	6
OV	FNDC3A →	+0.295	+0.058	.005	.001	3	6
BRCA	TBCEL →	+0.324	+0.038	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003323 vs SLIT3 — PDAC

Explore this scatter interactively →