Type B pancreatic cell development

Across TCGA patient cohorts, RNA activity of the Type B pancreatic cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT1HL1, PPIAP77, and ATAD3C, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type B pancreatic cell development activity versus MT1HL1 in LUAD (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MT1HL1 →	-0.244	-0.321	.005	.004	3	3
COAD	PPIAP77 →	-0.223	-0.473	.001	.005	3	3
HNSC	ATAD3C →	-0.363	-0.125	.005	.002	3	3
PDAC	PGAM1P11 →	-0.327	-0.129	.004	.005	3	3
LUAD	ADGRF5-AS1 →	-0.891	-0.269	.002	.009	3	2
LUAD	ANKRD65 →	-0.841	-0.380	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003323 vs MT1HL1 — LUAD

Explore this scatter interactively →