Type B pancreatic cell development

Across TCGA cell cohorts, RNA activity of the Type B pancreatic cell development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD45, COL23A1, and LYPLA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKRD45 grouped by Type B pancreatic cell development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANKRD45 →	-0.235	-0.481	.002	.007	3	4
KIDNEY	COL23A1 →	-1.483	-0.903	.009	.005	3	4
LUNG_NSCLC_LUSC	LYPLA2 →	-0.567	-0.240	.005	.004	3	4
BONE	ZNF844 →	+1.024	+0.393	.003	.006	3	3
BREAST	ENDOD1 →	-1.389	-0.621	<.001	.006	3	3
LUNG_NSCLC_LUSC	KBTBD6 →	+1.218	+0.336	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKRD45 by Type B pancreatic cell development activity — BREAST

Explore this box plot interactively →