Positive regulation of blood pressure by epinephrine-norepinephrine

Across TCGA patient cohorts, RNA activity of the Positive regulation of blood pressure by epinephrine-norepinephrine pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AFDN_S1275, SLAIN2_S413, and SEPTIN9_S30, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood pressure by epinephrine-norepinephrine activity versus AFDN_S1275 in LSCC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AFDN_S1275 →	-0.370	-0.086	<.001	<.001	3	5
LUAD	SLAIN2_S413 →	-0.697	-0.157	<.001	<.001	3	4
PDAC	SEPTIN9_S30 →	-0.319	-0.088	<.001	<.001	3	4
PDAC	HSPH1 →	-0.203	-0.078	<.001	.001	3	4
LUAD	PDE4D_S754 →	+1.039	+0.170	<.001	<.001	3	4
HNSC	PARD6B →	-0.455	-0.095	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003321 vs AFDN_S1275 — LSCC

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