Positive regulation of blood pressure by epinephrine-norepinephrine

Across TCGA patient cohorts, RNA activity of the Positive regulation of blood pressure by epinephrine-norepinephrine pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMTN, ATRX_S634, and VCL_S579, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood pressure by epinephrine-norepinephrine activity versus SMTN in COAD (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SMTN →	+0.692	+0.260	<.001	<.001	3	4
UCEC	ATRX_S634 →	+1.602	+1.591	.001	<.001	3	3
OV	VCL_S579 →	+1.571	+0.808	<.001	.001	3	3
OV	FAM122A_S173 →	+0.749	+0.920	<.001	.001	3	3
OV	PRPH_S50 →	+1.087	+0.072	.007	<.001	3	3
COAD	RPL18 →	-0.315	-0.202	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003321 vs SMTN — COAD

Explore this scatter interactively →