Positive regulation of blood pressure by epinephrine-norepinephrine

Across TCGA cell cohorts, RNA activity of the Positive regulation of blood pressure by epinephrine-norepinephrine pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIR, MAPK7, and DAPK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIR grouped by Positive regulation of blood pressure by epinephrine-norepinephrine-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TRIR →	+0.810	+1.124	.001	<.001	3	4
STOMACH	MAPK7 →	+1.022	+1.116	<.001	.002	3	4
LUNG_NSCLC_LUSC	DAPK3 →	+1.444	+2.012	.003	<.001	3	4
SOFT_TISSUE	HSD17B1 →	-2.198	-1.061	<.001	.003	3	4
CNS	SEPTIN1 →	-0.853	-1.541	.003	.004	3	4
LUNG_NSCLC_LUSC	RANGAP1 →	+0.887	+1.199	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIR by Positive regulation of blood pressure by epinephrine-norepinephrine activity — STOMACH

Explore this box plot interactively →