Positive regulation of blood pressure by epinephrine-norepinephrine

Across TCGA cell cohorts, RNA activity of the Positive regulation of blood pressure by epinephrine-norepinephrine pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACLY, WDFY1, and MAX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACLY grouped by Positive regulation of blood pressure by epinephrine-norepinephrine-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ACLY →	-0.336	-0.089	.001	<.001	3	6
LUNG_SCLC	WDFY1 →	-0.215	-0.233	<.001	.003	3	5
BONE	MAX →	-0.585	-0.683	.007	<.001	3	5
KIDNEY	CCL11 →	-0.329	-0.032	.002	.002	3	5
OVARY	WWP2 →	-0.280	-0.105	<.001	<.001	3	4
SKIN	KCNQ2 →	-0.226	-0.199	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACLY by Positive regulation of blood pressure by epinephrine-norepinephrine activity — OVARY

Explore this box plot interactively →