Pancreatic A cell differentiation

Across TCGA patient cohorts, RNA activity of the Pancreatic A cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAGI1, PLOD1, and SMC1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pancreatic A cell differentiation activity versus MAGI1 in GBM (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAGI1 →	+0.423	+0.090	<.001	<.001	3	5
HNSC	PLOD1 →	-0.376	-0.114	.001	.002	3	5
GBM	SMC1A →	+0.218	+0.051	.001	.004	3	4
PDAC	TMEM230_S24 →	-0.570	-0.099	<.001	<.001	3	4
PDAC	UBXN4 →	-0.253	-0.089	<.001	.002	3	4
GBM	CDH11_S788 →	-0.774	-0.094	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003310 vs MAGI1 — GBM

Explore this scatter interactively →