Type B pancreatic cell differentiation

Across TCGA patient cohorts, RNA activity of the Type B pancreatic cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CFHR2, CNDP1, and FMNL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type B pancreatic cell differentiation activity versus CFHR2 in LSCC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CFHR2 →	+0.720	+0.049	<.001	.008	3	6
OV	CNDP1 →	+0.476	+0.045	.001	.003	3	6
OV	FMNL3 →	+0.264	+0.039	.006	.001	3	6
BRCA	TBCEL →	+0.344	+0.041	<.001	<.001	3	6
BRCA	RASIP1 →	+0.305	+0.029	.004	.007	3	6
LUAD	PEAK1 →	+0.178	+0.041	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003309 vs CFHR2 — LSCC

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