Type B pancreatic cell differentiation

Across TCGA patient cohorts, RNA activity of the Type B pancreatic cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP13_S1906, PTPN21_S673, and PHACTR4_S443, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type B pancreatic cell differentiation activity versus AKAP13_S1906 in CCRCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AKAP13_S1906 →	+0.592	+0.923	.002	<.001	3	3
HNSC	PTPN21_S673 →	+0.935	+0.528	.004	<.001	3	3
UCEC	PHACTR4_S443 →	+0.639	+0.209	.001	<.001	3	2
HNSC	RERE_S679 →	-0.427	-0.167	<.001	<.001	3	2
LSCC	SCAF4_S1037 →	-0.459	-0.970	.007	.002	3	2
HNSC	STAG1_S1065 →	-0.370	-0.166	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003309 vs AKAP13_S1906 — CCRCC

Explore this scatter interactively →