Type B pancreatic cell differentiation

Across TCGA cell cohorts, RNA activity of the Type B pancreatic cell differentiation pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are FGFR_0939, TTK_3146, and Vinorelbine, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FGFR_0939 grouped by Type B pancreatic cell differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FGFR_0939 →	+0.564	+1.322	.009	.003	3	3
LUNG_SCLC	TTK_3146 →	+0.897	+1.369	.001	.003	3	3
LUNG_SCLC	Vinorelbine →	+0.873	+1.153	<.001	<.001	3	3
LUNG_SCLC	BAY-HDAC11_2 →	+0.929	+1.197	<.001	.004	3	2
LUNG_NSCLC_LUAD	EHT-1864 →	-0.200	-1.765	.048	.002	3	2
LUNG_SCLC	AZD8835 →	+0.911	+1.388	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FGFR_0939 by Type B pancreatic cell differentiation activity — LUNG_SCLC

Explore this box plot interactively →