Wnt signaling pathway involved in heart development

pathway activity — cross-omics
GO:0003306Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Wnt signaling pathway involved in heart development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT1, WNT5A, and RHPN2_S654, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCFERMT1 →+0.525+0.082<.001<.00136
LSCCWNT5A →+0.999+0.112<.001<.00135
PDACRHPN2_S654 →+0.539+0.084<.001.00635
OVMISP_S575 →+0.697+0.098.002.00134
PDACPLEKHA5_S382 →+0.989+0.126.008.00225
PDACIRS2_S594 →+0.951+0.139<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration