Physiological cardiac muscle hypertrophy

Across TCGA patient cohorts, RNA activity of the Physiological cardiac muscle hypertrophy pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, SGCD, and GSN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Physiological cardiac muscle hypertrophy activity versus PRKG1 in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PRKG1 →	+0.639	+0.070	<.001	<.001	3	9
BRCA	SGCD →	+0.752	+0.049	<.001	<.001	3	8
BRCA	GSN →	+0.748	+0.050	<.001	<.001	3	8
BRCA	TPM1 →	+0.506	+0.042	<.001	<.001	3	7
CCRCC	VCL →	+0.491	+0.063	<.001	<.001	3	7
BRCA	CTIF →	+0.398	+0.043	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003301 vs PRKG1 — CCRCC

Explore this scatter interactively →