Physiological cardiac muscle hypertrophy

Across TCGA patient cohorts, RNA activity of the Physiological cardiac muscle hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NTRK3, FEZ1, and SPARCL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Physiological cardiac muscle hypertrophy activity versus NTRK3 in CCRCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NTRK3 →	+0.367	+0.416	.005	<.001	3	7
GBM	FEZ1 →	+0.610	+0.606	.006	.001	3	7
LUAD	SPARCL1 →	+0.613	+0.159	.004	.008	3	6
GBM	NALCN →	+1.126	+0.730	<.001	<.001	3	6
GBM	PDE1A →	+0.906	+0.412	<.001	.001	3	6
BRCA	LMOD1 →	+0.825	+0.355	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003301 vs NTRK3 — CCRCC

Explore this scatter interactively →