Physiological cardiac muscle hypertrophy

Across TCGA cell cohorts, RNA activity of the Physiological cardiac muscle hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA3B, MTMR2, and PDGFB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEMA3B grouped by Physiological cardiac muscle hypertrophy-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SEMA3B →	-2.844	-1.349	<.001	.002	3	5
LUNG_NSCLC_LUSC	MTMR2 →	-0.796	-1.576	.003	.006	3	5
BREAST	PDGFB →	-1.636	-1.169	.001	<.001	3	4
LARGE_INTESTINE	PPM1K →	-1.851	-1.319	<.001	.002	3	4
BREAST	CMYA5 →	-1.109	-1.084	<.001	<.001	3	4
BREAST	FRS2 →	-1.114	-0.848	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEMA3B by Physiological cardiac muscle hypertrophy activity — OESOPHAGUS

Explore this box plot interactively →