Physiological cardiac muscle hypertrophy

Across TCGA cell cohorts, RNA activity of the Physiological cardiac muscle hypertrophy pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGST1, PYROXD1, and PSMB8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MGST1 grouped by Physiological cardiac muscle hypertrophy-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MGST1 →	-0.233	-1.587	.005	<.001	3	4
BLOOD_Lymphoma	PYROXD1 →	+0.586	+1.738	.008	<.001	3	4
URINARY_TRACT	PSMB8 →	+0.382	+0.522	.003	<.001	3	3
URINARY_TRACT	P3H2 →	+0.198	+0.348	.009	.003	3	3
BLOOD_Myeloma	SCAMP5 →	+0.319	+1.643	<.001	<.001	3	3
BREAST	SLAMF7 →	+0.122	+0.396	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MGST1 by Physiological cardiac muscle hypertrophy activity — BLOOD_Myeloma

Explore this box plot interactively →