Physiological cardiac muscle hypertrophy

Across TCGA cell cohorts, RNA activity of the Physiological cardiac muscle hypertrophy pathway is significantly associated with the drug response of multiple features, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are AICA Ribonucleotide, Bosutinib, and RO-3306, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AICA Ribonucleotide grouped by Physiological cardiac muscle hypertrophy-low versus -high activity in SKIN.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AICA Ribonucleotide →	-1.040	-1.763	.005	.004	1	1
SKIN	Bosutinib →	-0.550	-1.763	.012	.004	1	1
SKIN	RO-3306 →	-0.390	-1.763	.011	.004	1	1
SKIN	Dasatinib →	-0.320	-1.763	.004	.004	1	1
SKIN	XMD11-85h →	-0.774	-1.763	.021	.004	1	1
SKIN	ZG-10 →	-0.390	-1.763	.023	.004	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AICA Ribonucleotide by Physiological cardiac muscle hypertrophy activity — SKIN

Explore this box plot interactively →