Muscle hypertrophy in response to stress

Across TCGA cell cohorts, RNA activity of the Muscle hypertrophy in response to stress pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTK2B, FGD2, and TRAT1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTK2B grouped by Muscle hypertrophy in response to stress-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PTK2B →	+0.378	+0.241	.002	.006	3	2
CNS	FGD2 →	-0.220	-0.313	.004	.003	3	2
CNS	TRAT1 →	+0.305	+0.241	.003	.006	3	2
BLOOD_Leukemia	GTPBP6 →	+0.195	+0.299	.001	.005	3	2
BLOOD_Leukemia	RNF182 →	+0.252	+0.299	.001	.005	3	2
BLOOD_Leukemia	RFXANK →	+0.136	+0.299	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTK2B by Muscle hypertrophy in response to stress activity — CNS

Explore this box plot interactively →