Muscle hypertrophy in response to stress

Across TCGA cell cohorts, RNA activity of the Muscle hypertrophy in response to stress pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA6L4, NPIPB9, and CENPM, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle hypertrophy in response to stress activity versus GOLGA6L4 in CNS (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GOLGA6L4 →	+0.684	+0.199	<.001	.005	3	2
CNS	NPIPB9 →	+0.683	+0.297	.001	.001	3	2
STOMACH	CENPM →	+1.066	+0.124	.001	.002	3	2
STOMACH	MAP4K3 →	-1.236	-0.124	.002	.002	3	2
STOMACH	CHRNB4 →	-0.275	-0.135	<.001	.005	3	2
STOMACH	PMS2 →	-0.653	-0.124	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003299 vs GOLGA6L4 — CNS

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