Atrial septum development

Across TCGA patient cohorts, RNA activity of the Atrial septum development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK2, PTGDS, and CHRDL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrial septum development activity versus ANK2 in CCRCC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANK2 →	+0.970	+0.484	<.001	<.001	3	7
GBM	PTGDS →	+1.085	+0.753	<.001	<.001	3	5
LSCC	CHRDL1 →	+1.181	+0.385	.001	<.001	3	5
LUAD	ABI3BP →	+0.737	+0.362	.001	.001	3	5
LUAD	ANKRD55 →	+0.289	+0.336	<.001	<.001	3	5
CCRCC	CCL19 →	+1.131	+0.444	.002	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003283 vs ANK2 — CCRCC

Explore this scatter interactively →