Atrial septum development

Across TCGA cell cohorts, RNA activity of the Atrial septum development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCRN1, UBE2W, and DDB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCRN1 grouped by Atrial septum development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SCRN1 →	-4.661	-1.386	<.001	<.001	3	6
KIDNEY	UBE2W →	-0.750	-1.407	.001	<.001	3	5
BLOOD_Leukemia	DDB2 →	+1.274	+0.621	<.001	.002	3	4
OVARY	RPN1 →	-0.764	-1.198	<.001	<.001	3	4
STOMACH	VASN →	-2.026	-1.088	.002	.001	3	4
OVARY	RAB40A →	-0.578	-0.744	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCRN1 by Atrial septum development activity — STOMACH

Explore this box plot interactively →