Atrial septum development

Across TCGA cell cohorts, RNA activity of the Atrial septum development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2S, RUNX2, and CETN2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrial septum development activity versus UBE2S in LUNG_NSCLC_LUAD (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UBE2S →	+0.834	+1.597	.001	<.001	3	3
PANCREAS	RUNX2 →	+0.957	+1.583	.007	.001	3	3
LIVER	CETN2 →	+1.703	+2.039	.001	<.001	3	2
KIDNEY	SAAL1 →	+1.020	+1.429	.002	<.001	3	2
CNS	TYW1 →	-0.421	-0.854	.006	.005	3	2
CNS	TBC1D22B →	+0.538	+1.140	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003283 vs UBE2S — LUNG_NSCLC_LUAD

Explore this scatter interactively →