Ventricular septum development

Across TCGA patient cohorts, RNA activity of the Ventricular septum development pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCHS1, GARRE1, and PEAK1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular septum development activity versus DCHS1 in UCS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	DCHS1 →	+1.623	+0.057	<.001	.001	3	33
THYM	GARRE1 →	+1.076	+0.049	<.001	<.001	3	33
THYM	PEAK1 →	+1.378	+0.059	<.001	<.001	3	33
THYM	F2R →	+2.632	+0.058	<.001	<.001	3	33
THYM	PDGFRB →	+1.456	+0.050	<.001	<.001	3	32
ACC	SF3B1 →	+1.070	+0.034	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003281 vs DCHS1 — UCS

Explore this scatter interactively →