Ventricular septum development

Across TCGA patient cohorts, RNA activity of the Ventricular septum development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN2, SEPTIN4, and SORBS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular septum development activity versus SEPTIN2 in PDAC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEPTIN2 →	+0.263	+0.034	<.001	.001	3	9
OV	SEPTIN4 →	+0.717	+0.056	<.001	<.001	3	9
CCRCC	SORBS1 →	+0.718	+0.059	<.001	<.001	3	9
LSCC	CNN3 →	+0.679	+0.042	<.001	<.001	3	9
OV	FHL3 →	+0.983	+0.067	<.001	<.001	3	9
CCRCC	FMNL3 →	+0.437	+0.070	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003281 vs SEPTIN2 — PDAC

Explore this scatter interactively →