Ventricular septum development

Across TCGA patient cohorts, RNA activity of the Ventricular septum development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, FGF18, and CILP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular septum development activity versus THBS1 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THBS1 →	+0.987	+0.447	.001	.001	3	4
UCEC	FGF18 →	+1.131	+0.259	<.001	.005	3	4
BRCA	CILP2 →	+0.957	+0.394	<.001	<.001	3	4
BRCA	ACTA2-AS1 →	+0.807	+0.343	.004	.005	3	4
HNSC	LHFPL6 →	+0.390	+0.467	.001	.001	3	4
UCEC	CNN3 →	+0.628	+0.244	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003281 vs THBS1 — BRCA

Explore this scatter interactively →