Regulation of membrane depolarization

Across TCGA patient cohorts, RNA activity of the Regulation of membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEF2C, SEMA3G, and DMXL2, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane depolarization activity versus MEF2C in UCS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	MEF2C →	+1.624	+0.039	<.001	<.001	3	27
UCS	SEMA3G →	+1.106	+0.029	<.001	.001	3	26
DLBC	DMXL2 →	+1.130	+0.053	.001	<.001	3	26
THYM	LHX4 →	+0.550	+0.040	<.001	<.001	3	26
ESCA	PTPRB →	+1.030	+0.030	<.001	<.001	3	26
DLBC	AGO4 →	+1.050	+0.046	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003254 vs MEF2C — UCS

Explore this scatter interactively →